Thomas LaFramboise Assistant Professor Ph.D. Training Faculty

Department of Genetics School of Medicine Case Western Reserve University Biomedical Research Building 630 2109 Adelbert Road Cleveland, Ohio 44106-4955 Tel: (216) 368-0150 Fax: (216) 368-3432 E-mail: thomas.laframboise@case.edu

About Thomas Laframboise

Tom LaFramboise earned his B.S. from the University of Michigan at Ann Arbor and his Ph.D. from the University of Illinois at Urbana-Champaign, both degrees in theoretical mathematics. Subsequently, he spent several years as Assistant and Associate Professor in the mathematics department at Marietta College in Marietta, OH. In 2002, Tom decided to retrain in biostatistics, earning a Master's degree at the Harvard School of Public Health, which led to a postdoctoral position in cancer genomics in the laboratory of Matthew Meyerson at the Dana-Farber Cancer Institute and the Broad Institute of Harvard/MIT. He joined the department in August 2006.

Research

Broadly, Dr. LaFramboise is interested in developing and applying computational tools to identify molecular variants, both inherited and somatic, that contribute to cancer and other diseases. He has written a number of R software packages designed to draw biological inferences from genomic data, and his group is currently working to mine high-dimensional SNP array data for inherited variants that predispose the cell to genomic instability. Related interests include the detection of germline copy number polymorphisms, their relevance in association studies, and developing statistical methodologies to optimize power in such studies.